DiscoverThe Evolving Wellness Podcast with Sarah Kleiner WellnessThe Real Reason Hormone Replacement Works For Some + Not Others | Kashif Khan
The Real Reason Hormone Replacement Works For Some + Not Others | Kashif Khan

The Real Reason Hormone Replacement Works For Some + Not Others | Kashif Khan

Update: 2025-06-25
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In this episode, I’m joined once again by my friend Kashif Khan to explore why the same supplement or treatment can help one person but harm another. We zero in on one surprising environmental trigger that affects nearly everyone differently: plug-in air fresheners, and how these little devices can quietly disrupt your hormones, energy, and detox pathways.

We also dive deeper into the genetic blueprint of the body, especially for those navigating perimenopause and considering hormone replacement therapy. If you’ve ever wondered why HRT works beautifully for some women but backfires for others, this conversation will help you understand how to personalize your approach and make more informed decisions.

Topics Discussed:

→ Why does hormone therapy work for some women but not others?

→ How does genetics influence supplement effectiveness?

→ What should women in perimenopause know before starting HRT?

→ How does your environment impact detox and inflammation?

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Timestamps:

00:00:00 - Introduction 

00:02:17 - Summary of previous masterclass

00:04:25 - Genetics and relationship dynamics  

00:09:01 - HRT overview 

00:16:23 - Customizing your life to your body

00:21:45 - Why progesterone can be tricky

00:25:06 - Personalizing detox

00:27:45 - Heavy metals & medical interventions

00:31:49 - Trauma responses & chronic inflammation

00:36:14 - Functional testing & lab work

00:42:01 - B12 & methylation

00:45:55 - Estrogen & root cause issues

00:50:34 - Movement & hormone balancing

00:53:27 - DHEA and pregnenolone supplementation

00:57:39 - Methylene blue

Show Links:

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Check Out Kashif:

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This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!

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The Real Reason Hormone Replacement Works For Some + Not Others | Kashif Khan

The Real Reason Hormone Replacement Works For Some + Not Others | Kashif Khan

Sarah Kleiner